ea0065p209 | Metabolism and Obesity | SFEBES2019
Ovadia Caroline
, Spagou Konstantina
, Perdones-Montero Alvaro
, Smith Ann
, Papacleovoulou Georgia
, Dixon Peter
, Holmes Elaine
, Marchesi Julian
, Williamson Catherine
Background: The 16-year-old children of mothers with intrahepatic cholestasis of pregnancy demonstrate increased adiposity, dyslipidaemia, and males have raised fasting insulin. Similarly, the offspring of cholestatic pregnant mice have impaired glucose tolerance and dyslipidaemia when challenged with a Western diet. Female offspring have a more marked phenotype than males. Bile influences microbial growth, thus intestinal bile acid exposure in pregnancy may contribute to meta...